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Insulin / IRDN (beta-Cell & Insulinoma Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone IRDN/794 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, IF, FC |
|---|---|
| Primary Accession | P01308 |
| Other Accession | 3630, 272259 |
| Reactivity | Human, Mouse, Rat, Pig, Bovine |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG1, kappa |
| Clone Names | IRDN/794 |
| Calculated MW | 6kDa |
| Gene ID | 3630 |
|---|---|
| Other Names | Insulin, Insulin B chain, Insulin A chain, INS |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | Insulin / IRDN (beta-Cell & Insulinoma Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | INS |
|---|---|
| Function | Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. |
| Cellular Location | Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.
References
Kahn, C.R. 1985. The molecular mechanism of Insulin action. Ann. Rev. Med. 36: 429-451. |
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