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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   Toll-Like receptor signaling   >    IL-6 (Interleukin-6) / Interferon beta-2 (Hybridoma Growth Factor) Antibody - With BSA and Azide   

IL-6 (Interleukin-6) / Interferon beta-2 (Hybridoma Growth Factor) Antibody - With BSA and Azide

Rat Monoclonal Antibody [Clone IL6/1270 ]

     
  • IHC -  IL-6 (Interleukin-6) / Interferon beta-2 (Hybridoma Growth Factor) Antibody - With BSA and Azide AH11578-20
    Formalin-fixed, paraffin-embedded human Esophageal Carcinoma stained with IL-6 Monoclonal Antibody (IL6/1270).
    detail
  • IHC -  IL-6 (Interleukin-6) / Interferon beta-2 (Hybridoma Growth Factor) Antibody - With BSA and Azide AH11578-20
    Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with IL-6 Monoclonal Antibody (IL6/1270).
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC, IF, FC
Primary Accession P05231
Other Accession 3569, 654458
Reactivity Human, Mouse
Host Rat
Clonality Monoclonal
Isotype Rat / IgG1, kappa
Clone Names IL6/1270
Calculated MW 21kDa
Additional Information
Gene ID 3569
Other Names Interleukin-6, IL-6, B-cell stimulatory factor 2, BSF-2, CTL differentiation factor, CDF, Hybridoma growth factor, Interferon beta-2, IFN-beta-2, IL6, IFNB2
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions IL-6 (Interleukin-6) / Interferon beta-2 (Hybridoma Growth Factor) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL6 (HGNC:6018)
Synonyms IFNB2
Function Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable). The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans- signaling'. Alternatively, 'cluster signaling' occurs when membrane- bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable).
Cellular Location Secreted.
Tissue Location Produced by skeletal muscle.
Research Areas
Citations (0)
citation

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Background

IL-6 is a potent lymphoid cell growth factor that stimulates the growth and survivability of certain B-cells and T-cells. It plays a critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. IL-6 is produced by a variety of cell types, including monocytes, fibroblasts and endothelial cells. Upon stimulation, macrophages, T, B, mast, and glial cells, eosinophils, keratinocytes and granulocytes also secrete IL-6. It is involved in host defense, acute phase reactions, immune responses, and hematopoiesis.

References

Hirano, T., et al. 1986. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 324: 73-76

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$ 219.00
$ 499.00
Cat# AH11578-20
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