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CD54 / ICAM-1 Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone F4-31C2 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IF, FC |
|---|---|
| Primary Accession | P05362 |
| Other Accession | 3383, 643447 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG1, kappa |
| Clone Names | F4-31C2 |
| Calculated MW | 85-115kDa |
| Gene ID | 3383 |
|---|---|
| Other Names | Intercellular adhesion molecule 1, ICAM-1, Major group rhinovirus receptor, CD54, ICAM1 |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | CD54 / ICAM-1 Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ICAM1 |
|---|---|
| Function | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Recognizes an 85-115kDa protein (variation with cell type), identified as intercellular adhesion molecule (ICAM-1). It has 7 potential N-linked glycosylation sites. ICAM-1 is a single chain glycoprotein of Ig supergene family, present on unstimulated endothelial cells (EC) and on a variety of other cell types including activated fibroblasts, EC, macrophages, and lymphocytes. ICAM-1 mediates cell adhesion by binding to integrins CD11a/CD18 (leukocyte adhesion molecule, LFA-1) and to CD11b/CD18 (Mac-1). This interaction enhances antigen-specific T-cell activation. ICAM-1 also binds to CD43 and to Plasmodium falciparum infected RBCs. ICAM-1 may also be related to progression and metastasis of tumors.
References
Johnson, J.P., et al., Cluster Report: CD54, in: Knapp, W., et al. (eds), Leucocyte Typing IV, Oxford Univ. Press, pp 681-683
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