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Tenascin C (Stromal Marker For Epithelial Malignancy) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone SPM319 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, IF, FC |
|---|---|
| Primary Accession | P24821 |
| Other Accession | 3371, 143250 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG1, kappa |
| Clone Names | SPM319 |
| Calculated MW | 210kDa and 300kDa |
| Gene ID | 3371 |
|---|---|
| Other Names | Tenascin, TN, Cytotactin, GMEM, GP 150-225, Glioma-associated-extracellular matrix antigen, Hexabrachion, JI, Myotendinous antigen, Neuronectin, Tenascin-C, TN-C, TNC, HXB |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | Tenascin C (Stromal Marker For Epithelial Malignancy) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TNC |
|---|---|
| Synonyms | HXB |
| Function | Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha- V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327). |
| Cellular Location | Secreted, extracellular space, extracellular matrix |
| Tissue Location | Detected in fibroblasts (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
In Western blotting, it reacts with two bands of ~MW of 210kDa and 300kDa, identified as two isoforms of Tenascin C. Specificity of this MAb is validated by sequential immunoprecipitation with a PAb against Tenascin C. Tenascin C is a multifunctional, disulfide-linkedĀhexameric extracellular matrix glycoprotein expressed in association with mesenchymal epithelial interactions during development and in the neo-vasculature and stroma of undifferentiated tumors. In adults, it is restricted to certain epithelial-stromal interfaces and increases markedly in hyper-proliferative diseases and in stroma of many neoplasms, including gliomas, breast, squamous and lung carcinomas.
References
Verstraeten AA, et. al. British Journal of Dermatology, 1992, 127(6):571-4. |
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