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AMP Deaminase, Isoform E (AMPD3) (Erythroid Marker) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone AMPD3/901 ]

     
  • IHC -  AMP Deaminase, Isoform E (AMPD3) (Erythroid Marker) Antibody - With BSA and Azide AH11326-20
    Formalin-fixed, paraffin-embedded human Tonsil stained with AMPD3 Monoclonal Antibody (AMPD3/901)
    detail
  • IHC -  AMP Deaminase, Isoform E (AMPD3) (Erythroid Marker) Antibody - With BSA and Azide AH11326-20
    Formalin-fixed, paraffin-embedded human Placenta stained with AMPD3 Monoclonal Antibody (AMPD3/901)
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-F, IF, FC, ICC
Primary Accession Q01432
Other Accession 272, 501890
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2b, kappa
Clone Names AMPD3/901
Calculated MW ~90kDa
Additional Information
Gene ID 272
Other Names AMP deaminase 3, 3.5.4.6, AMP deaminase isoform E, Erythrocyte AMP deaminase, AMPD3
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions AMP Deaminase, Isoform E (AMPD3) (Erythroid Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AMPD3 (HGNC:470)
Function AMP deaminase plays a critical role in energy metabolism.
Research Areas
Citations (0)
citation

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Background

It recognizes a protein of ~90kDa, which is identified as Adenosine Monophosphate Deaminase, isoform E (AMPD3). It has 767 amino acids and is assigned an EC 3.5.4.6. It is a highly regulated enzyme that catalyzes the hydrolytic deamination of adenosine monophosphate to inosine monophosphate, a branch point in the adenylate catabolic pathway. AMPD3 gene encodes the erythrocyte (E) isoforms, whereas other family members encode isoforms that predominate in muscle (M) and liver (L) cells. This MAb shows reactivity with cells of the erythroid lineage at all stages of maturation in the peripheral blood, bone marrow, and fetal liver. Non-erythroid lineages are negative by flow cytometry. This MAb is useful in the diagnosis of erythroleukemia, identification of bone marrow erythroid precursors, gating erythroid nucleated precursor cells from malignant cells in bone marrow specimens.

References

Sabina RL, Waldenstrm A, Ronquist G. The contribution of Ca+ calmodulin activation of human erythrocyte AMP deaminase (isoform E) to the erythrocyte metabolic dysregulation of familial phosphofructokinase deficiency. Haematologica. 2006;91(5):652-5

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$ 219.00
$ 499.00
Cat# AH11326-20
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