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TRIM29 (Lung Squamous Cell Carcinoma Marker) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone TRIM29/1042 ]

     
  • WB -  TRIM29 (Lung Squamous Cell Carcinoma Marker) Antibody - With BSA and Azide AH11236-20
    Western Blot of TRIM29 Recombinant protein fragment & A431 Cell Lysate TRIM29 Monoclonal Antibody (TRIM29/1042).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IF, FC
Primary Accession Q14134
Other Accession 23650, 504115
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2b, kappa
Clone Names TRIM29/1042
Calculated MW 66kDa
Additional Information
Gene ID 23650
Other Names Tripartite motif-containing protein 29, Ataxia telangiectasia group D-associated protein, TRIM29, ATDC
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions TRIM29 (Lung Squamous Cell Carcinoma Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM29
Synonyms ATDC
Function Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
Cellular Location Cytoplasm. Lysosome. Note=Colocalizes with intermediate filaments
Tissue Location Expressed in placenta, prostate and thymus.
Research Areas
Citations (0)
citation

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Background

It recognizes a 66kDa protein, which is identified as Tripartite motif-containing protein 29 (TRIM29). It interacts with the intermediate filament protein vimentin, a substrate for the PKC family of protein kinases, and with hPKCI-1, an inhibitor of the PKCs. TRIM29 protein contains both zinc finger and leucine zipper motifs, suggesting that the it may form homodimers and possibly associate with DNA. High expression of TRIM29 has been reported in gastric cancer and pancreatic cancer, and correlates with enhanced tumor growth and lymph node metastasis. TRIM29 is also able to distinguish lung squamous cell carcinoma from lung adenocarcinoma with ~90% positive accuracy, when used in a panel with TTF-1, p63, CK5/6, and Napsin-A antibodies.

References

Kosaka Y, et al. Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer. Ann Surg Oncol. 14(9): 2543-9. 2007. | Ring BZ, et al. A novel five-antibody immunohistochemical test for sub-classification of lung carcinoma. Mod Pathol. 22(8): 1032-43. 2009

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$ 219.00
$ 499.00
Cat# AH11236-20
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