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AFP (Alpha Fetoprotein) (Hepatocellular/Germ Cell Tumor Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone C2 + C3 + MBS-12 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, IF, FC |
|---|---|
| Primary Accession | P02771 |
| Other Accession | 174, 518808 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG's |
| Clone Names | C2 + C3 + MBS-12 |
| Calculated MW | 70kDa |
| Gene ID | 174 |
|---|---|
| Other Names | Alpha-fetoprotein, Alpha-1-fetoprotein, Alpha-fetoglobulin, AFP, HPAFP |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | AFP (Alpha Fetoprotein) (Hepatocellular/Germ Cell Tumor Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AFP |
|---|---|
| Synonyms | HPAFP |
| Function | Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. |
| Cellular Location | Secreted. |
| Tissue Location | Plasma. Synthesized by the fetal liver and yolk sac |
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Provided below are standard protocols that you may find useful for product applications.
Background
It recognizes an oncofetal glycoprotein with a single chain of 70kDa, which is identified as alpha fetoprotein (AFP). This MAb is highly specific to AFP and shows no cross-reaction with other oncofetal antigens or serum albumin. AFP is normally synthesized in the liver, intestinal tract, and yolk sac of the fetus. Antibody to AFP has been shown to be useful in detecting hepatocellular carcinomas (HCC) and germ cell neoplasms, especially yolk sac tumors.
References
Lafuste, P., et al. 2002. α-fetoprotein gene expression in early and full- term human trophoblast. Placenta 23: 600-612
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