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Prolactin Receptor (hPRL-Receptor) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone SPM213 ]

     
  • IHC -  Prolactin Receptor (hPRL-Receptor) Antibody - With BSA and Azide AH10683-20
    Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with Prolactin Receptor Monoclonal Antibody (SPM213).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P, IF, FC
Primary Accession P16471
Other Accession 5618, 368587
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names SPM213
Calculated MW 70kDa
Additional Information
Gene ID 5618
Other Names Prolactin receptor, PRL-R, PRLR
Format 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Prolactin Receptor (hPRL-Receptor) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRLR
Function This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Expressed in breast, placenta, kidney, liver and pancreas.
Research Areas
Citations (0)
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Background

It recognizes a protein of 70kDa, identified as prolactin receptor. Prolactin is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. The initial step in its action is the binding to a specific membrane receptor (prolactin receptor), which belongs to the superfamily of class 1 cytokine receptors. The function of the prolactin receptor is mediated, at least in part, by two families of signaling molecules: Janus kinases and signal transducers and activators of transcription.

References

Br J Cancer. 2011;104(10):1641-8. | Breast Cancer Res. 2008;10(4):R68. | Histopathology. 2008;53(1):56-61. | Mod Pathol. 2010;23(7):961-71. | Breast Cancer Res Treat. 2011;128(1):31-40

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$ 219.00
$ 499.00
Cat# AH10683-20
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