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NKX2.2 (Neuroendocrine & Ewing Sarcoma Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone SPM564 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IF, FC |
|---|---|
| Primary Accession | O95096 |
| Other Accession | 4821, 516922 |
| Reactivity | Human, Mouse, Chicken |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG2b, kappa |
| Clone Names | SPM564 |
| Calculated MW | 40-50kDa |
| Gene ID | 4821 |
|---|---|
| Other Names | Homeobox protein Nkx-2.2, Homeobox protein NK-2 homolog B, NKX2-2, NKX2.2, NKX2B |
| Format | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | NKX2.2 (Neuroendocrine & Ewing Sarcoma Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NKX2-2 |
|---|---|
| Synonyms | NKX2.2, NKX2B |
| Function | Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.
References
Wang, Y.C. et al. (2009) Endocr Relat Cancer 16, 267-79. | Yoshida A et. al. Am J Surg Pathol. 2012;36(7):993-9
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