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MUC5AC (Mucin 5AC / Gastric Mucin) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone SPM297 ]

     
  • IHC -  MUC5AC (Mucin 5AC / Gastric Mucin) Antibody - With BSA and Azide AH10610-20
    Formalin-fixed, paraffin-embedded human Gastric Carcinoma stained with MUC5AC Monoclonal Antibody (SPM297).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P, IF, FC
Primary Accession P98088
Other Accession 4586, 534332
Reactivity Human, Mouse, Rat, Rabbit, Monkey, Pig, Chicken, Cat
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names SPM297
Calculated MW >1,000kDa
Additional Information
Gene ID 4586
Other Names Mucin-5AC, MUC-5AC, Gastric mucin, Lewis B blood group antigen, LeB, Major airway glycoprotein, Mucin-5 subtype AC, tracheobronchial, Tracheobronchial mucin, TBM, MUC5AC, MUC5
Format 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions MUC5AC (Mucin 5AC / Gastric Mucin) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MUC5AC {ECO:0000303|PubMed:11535137, ECO:0000312|HGNC:HGNC:7515}
Function Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370). Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999).
Cellular Location Secreted
Tissue Location Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum.
Research Areas
Citations (0)
citation

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Background

This MAb recognizes the peptide core of gastric mucin M1 (>1,000kDa) (recently identified as Mucin 5AC). Its epitope is destroyed by beta-mercaptoethanol and proteases but not by periodate treatment. Antibody to gastric mucin M1 reacts with the gastric epithelium of normal human gastrointestinal tract as well as with the precancerous and cancerous colon but not with normal adult colon. It also reacts with fetal colonic mucosa. Resurgence of gastric mucin reactivity during colonic carcinogenesis is due to re-expression of the peptide core of gastric (or fetal colonic) mucins.

References

Bara J et. al. International Journal of Cancer, 1991, 47(2):304-10. | Bara J et. al. Journal of Immunological Methods, 1992, 149(1):105-13

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$ 219.00
$ 499.00
Cat# AH10610-20
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