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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   Immune system process   >    IgG (Immunoglobulin Gamma Heavy Chain) (B-Cell Marker) Antibody - With BSA and Azide   

IgG (Immunoglobulin Gamma Heavy Chain) (B-Cell Marker) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone IG217 ]

     
  • IHC -  IgG (Immunoglobulin Gamma Heavy Chain) (B-Cell Marker) Antibody - With BSA and Azide AH10496-20
    Formalin-fixed, paraffin-embedded human Tonsil stained with IgG Monoclonal Antibody (IG217)
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P, IF, FC
Primary Accession P01857
Other Accession 3500 (IGHG1), 3501 (IGHG2), 3502 (IGHG3), 3503 (IGHG4), 510635, P01859, P01860, P01861
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names IG217
Calculated MW 75kDa
Additional Information
Other Names Ig gamma-1 chain C region, IGHG1
Format 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions IgG (Immunoglobulin Gamma Heavy Chain) (B-Cell Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IGHG1 {ECO:0000303|PubMed:11340299, ECO:0000303|Ref.13}
Function Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins- secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Mediates IgG effector functions on monocytes triggering ADCC of virus- infected cells.
Cellular Location [Isoform 1]: Secreted
Research Areas
Citations (0)
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Background

Recognizes a protein of 75kDa, identified as γ heavy chain of human immunoglobulins. It reacts with all sub-classes of γ chain of human immunoglobulins. It does not cross-react with α (IgA), μ (IgM), ε (IgE), or δ (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. This MAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin�s lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

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$ 219.00
$ 499.00
Cat# AH10496-20
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