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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   Lysosome   >   CD63 (Late Endosomes Marker)Mouse Monoclonal Antibody [Clone MX-49.129.5]    

CD63 (Late Endosomes Marker)Mouse Monoclonal Antibody [Clone MX-49.129.5]

Purified Mouse Monoclonal Antibody

     
  •  - CD63 (Late Endosomes Marker)Mouse Monoclonal Antibody [Clone MX-49.129.5]  AH10368-50
    Flow Cytometric staining of mouse CD63 on NIH/3T3 Cells. Black: Cells alone; Green: Isotype Control; Red: PE-labeled CD63 MAb (MX-49.129.5).
    detail
  •  - CD63 (Late Endosomes Marker)Mouse Monoclonal Antibody [Clone MX-49.129.5]  AH10368-50
    Flow Cytometric staining of CD63 on human PBMC Cells. Black: Cells alone; Green: Isotype Control; Red: PE-labeled CD63 MAb (MX-49.129.5).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IF, FC
Primary Accession P08962
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG1, kappa
Clone Names MX-49.129.5
Calculated MW 26kDa (core protein); 30-60kDa (glycosylated)
Additional Information
Gene ID 967
Other Names gp55; granulophysin; Lysosomal-associated membrane protein 3 (LAMP-3); Mast cell antigen AD1; melanoma 1 antigen; Melanoma-associated antigen MLA1; Melanoma-associated antigen ME491; MLA1; NGA; Ocular melanoma-associated antigen; OMA81H; PTLGP40; Tetraspanin-30; TSPAN30
Target/Specificity Full length CD63 of human origin
Application Note Flow Cytometry (5ul per test per one million cells or 5ul per 100ul of whole blood); Immunofluorescence (1:50-1:100); (Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes) Optimal dilution for a specific application should be determined.
Format 0.5ml at 100ug/ml with BSA and azide
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
PrecautionsCD63 (Late Endosomes Marker)Mouse Monoclonal Antibody [Clone MX-49.129.5] is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD63
Synonyms MLA1, TSPAN30
Function Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
Cellular Location Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endosome, multivesicular body. Melanosome. Secreted, extracellular exosome. Cell surface. Note=Also found in Weibel-Palade bodies of endothelial cells (PubMed:10793155). Located in platelet dense granules (PubMed:7682577). Detected in a subset of pre-melanosomes Detected on intralumenal vesicles (ILVs) within multivesicular bodies (PubMed:21962903).
Tissue Location Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.
Research Areas
Citations (0)
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References

1.    C. Vennegoor et al., Int. J. Cancer 35: 287-295, 1985.
2.  AA Palmer et al., Pathology 17: 335-339, 1985.
3. EC Hagen et al., Histopathology 10: 689-700, 1986.

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$ 429.00
Cat# AH10368-50
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