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CD45RB Antibody [Clone BRA-11; same as BRA-11G]

Purified Mouse Monoclonal Antibody

     
  •  - CD45RB Antibody [Clone BRA-11; same as BRA-11G] AH10088-50
    Formalin-fixed, paraffin-embedded human tonsil stained with CD45RB Ab (BRA-11).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
FC
Primary Accession P08575
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1, kappa
Clone Names BRA-11; same as BRA-11G
Calculated MW 180-220kDa
Additional Information
Gene ID 5788
Other Names Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, L-CA, T200, CD45, PTPRC, CD45
Target/Specificity Non-T, non-B CALLA positive ALL cell line REH (Leucocyte Workshop IV and V)
Application Note Flow Cytometry 2.5ul (0.5ug) per test per one million cells.
Format 0.5 ml at 100ug/ml; Conjugated to PE
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
PrecautionsCD45RB Antibody [Clone BRA-11; same as BRA-11G] is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTPRC (HGNC:9666)
Synonyms CD45
Function Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor (PubMed:35767951). Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein. Membrane raft. Synapse. Note=Colocalized with DPP4 in membrane rafts.
Tissue Location Isoform 1: Detected in thymocytes. Isoform 2: Detected in thymocytes. Isoform 3: Detected in thymocytes. Isoform 4: Not detected in thymocytes. Isoform 5: Detected in thymocytes. Isoform 6: Not detected in thymocytes. Isoform 7: Detected in thymocytes Isoform 8: Not detected in thymocytes.
Research Areas
Citations (0)
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Background

CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

References

1. Sedlak et al. Neoplasma 1989: 643, 1989.
2. Sutherland et.al Int. Immunol., 14(8): 953 – 962 (August 1, 2002)
3. Lim et.al Int. Immunol., 18(2):291-300 (2006)

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$ 429.00
Cat# AH10088-50
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