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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat anti-GP91-PHOX / NOX2 Antibody
Goat anti-GP91-PHOX / NOX2 Antibody
Peptide-affinity purified goat antibody
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Application 
| WB, Pep-ELISA |
|---|---|
| Primary Accession | P04839 |
| Other Accession | NP_000388.2 |
| Reactivity | Human, Mouse, Rat, Pig, Dog, Bovine |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | CYBB |
| Calculated MW | 65336 Da |
| Gene ID | 1536 |
|---|---|
| Other Names | CYBB; cytochrome b-245, beta polypeptide; CGD; GP91-1; GP91-PHOX; GP91PHOX; NOX2; p91-PHOX; CGD91-phox; NADPH oxidase 2; cytochrome b(558) subunit beta; cytochrome b-245 heavy chain; cytochrome b558 subunit beta; heme-binding membrane glycoprotein gp91pho |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-GP91-PHOX / NOX2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CYBB (HGNC:2578) |
|---|---|
| Synonyms | NOX2 |
| Function | Catalytic subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:15338276, PubMed:36241643, PubMed:36413210, PubMed:38355798). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (Probable) (PubMed:38355798). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (PubMed:19028840, PubMed:38355798). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity). NADPH oxidase complex assembly is impaired through interaction with NRROS (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Note=As unassembled monomer may localize to the endoplasmic reticulum |
| Tissue Location | Detected in neutrophils (at protein level). |
Research Areas
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$ 423.00
Cat# AF4526a
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