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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat anti-Cathepsin B (aa194-206) Antibody
Goat anti-Cathepsin B (aa194-206) Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
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- BACKGROUND
Application 
| IF, Pep-ELISA |
|---|---|
| Primary Accession | P07858 |
| Other Accession | NP_001899.1, NP_001304166.1 |
| Reactivity | Human, Rat, Pig, Dog, Bovine |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | CTSB |
| Calculated MW | 37822 Da |
| Gene ID | 1508 |
|---|---|
| Other Names | CTSB; cathepsin B; APPS; CPSB; APP secretase; amyloid precursor protein secretase; cathepsin B1; cysteine protease |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | Reported variants represent identical protein: NP_680091.1, NP_680090.1, NP_680092.1, NP_001899.1, NP_680093.1. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-Cathepsin B (aa194-206) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CTSB |
|---|---|
| Synonyms | CPSB |
| Function | Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (PubMed:3972105). |
| Cellular Location | Lysosome. Melanosome. Secreted, extracellular space {ECO:0000250|UniProtKB:A1E295}. Apical cell membrane {ECO:0000250|UniProtKB:P10605}; Peripheral membrane protein {ECO:0000250|UniProtKB:P10605}; Extracellular side {ECO:0000250|UniProtKB:P10605}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065) Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells (By similarity) {ECO:0000250|UniProtKB:P10605, ECO:0000269|PubMed:17081065} |
| Tissue Location | Expressed in the stratum spinosum of the epidermis. Weak expression is detected in the stratum granulosum |
Research Areas
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Application Protocols
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$ 341.00
Cat# AF4523a
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