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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat anti-TNFSF11 / OPGL Antibody
Goat anti-TNFSF11 / OPGL Antibody
Peptide-affinity purified goat antibody
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- BACKGROUND
Application 
| IF, FC, Pep-ELISA |
|---|---|
| Primary Accession | O14788 |
| Other Accession | NP_003692.1, NP_143026.1 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | TNFSF11 |
| Calculated MW | 35478 Da |
| Gene ID | 8600 |
|---|---|
| Other Names | TNFSF11; tumor necrosis factor (ligand) superfamily, member 11 ; ODF; OPGL; RANKL; TRANCE; hRANKL2; sOdf; TNF-related activation-induced cytokine; osteoclast differentiation factor; osteoprotegerin ligand; receptor activator of nuclear factor kappa B liga |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | This antibody is expected to recognise both reported isoforms (NP_003692.1 and NP_143026.1). |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-TNFSF11 / OPGL Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TNFSF11 |
|---|---|
| Synonyms | OPGL, RANKL, TRANCE |
| Function | Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity). |
| Cellular Location | [Isoform 1]: Cell membrane; Single-pass type II membrane protein [Isoform 2]: Cytoplasm. |
| Tissue Location | Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid |
Research Areas
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Application Protocols
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$ 423.00
Cat# AF4518a
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