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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat anti-NOTCH1 (aa171-182) Antibody
Goat anti-NOTCH1 (aa171-182) Antibody
Peptide-affinity purified goat antibody
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Application 
| IHC, IF, Pep-ELISA |
|---|---|
| Primary Accession | P46531 |
| Other Accession | NP_060087.3 |
| Reactivity | Human, Mouse, Rat, Dog, Bovine |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | NOTCH1 |
| Calculated MW | 272505 Da |
| Gene ID | 4851 |
|---|---|
| Other Names | NOTCH1; notch 1; TAN1; hN1; Notch homolog 1, translocation-associated; neurogenic locus notch homolog protein 1; translocation-associated notch protein TAN-1 |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-NOTCH1 (aa171-182) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NOTCH1 |
|---|---|
| Synonyms | TAN1 |
| Function | Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q01705}; Single-pass type I membrane protein |
| Tissue Location | In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues |
Research Areas
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Application Protocols
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$ 341.00
Cat# AF4505a
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