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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat anti-SOX2 Antibody
Goat anti-SOX2 Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, Pep-ELISA |
|---|---|
| Primary Accession | P48431 |
| Other Accession | NP_003097.1 |
| Reactivity | Human, Mouse, Rat, Pig, Dog, Bovine |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | SOX2 |
| Calculated MW | 34310 Da |
| Gene ID | 6657 |
|---|---|
| Other Names | SOX2; SRY (sex determining region Y)-box 2; ANOP3; MCOPS3; SRY-related HMG-box gene 2; transcription factor SOX-2; transcription factor SOX2 |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-SOX2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SOX2 |
|---|---|
| Function | Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Binds to the proximal enhancer region of NANOG (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:18035408). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity). |
| Cellular Location | Nucleus speckle {ECO:0000250|UniProtKB:Q05066}. Cytoplasm {ECO:0000250|UniProtKB:Q05738}. Nucleus {ECO:0000250|UniProtKB:Q05738}. Note=Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (By similarity). Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity) Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus (By similarity). Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor (By similarity) {ECO:0000250|UniProtKB:Q05066, ECO:0000250|UniProtKB:Q05738} |
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Application Protocols
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$ 341.00
Cat# AF4497a
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