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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat anti-Sgta (mouse aa84-97) Antibody
Goat anti-Sgta (mouse aa84-97) Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, Pep-ELISA |
|---|---|
| Primary Accession | O43765 |
| Other Accession | NP_078775.1 |
| Reactivity | Human, Mouse, Rat, Pig, Dog, Bovine |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | Sgta |
| Calculated MW | 34063 Da |
| Gene ID | 6449 |
|---|---|
| Other Names | Sgta; small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha; 5330427H01Rik; AI194281; D10Ertd190e; Sgt; Stg; alpha-SGT; small glutamine-rich tetratricopeptide repeat (TPR) containing protein; small glutamine-rich tetratricopeptide repeat-c |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-Sgta (mouse aa84-97) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SGTA |
|---|---|
| Synonyms | SGT, SGT1 |
| Function | Co-chaperone that binds misfolded and hydrophobic patches- containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail- anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:25535373, PubMed:28104892). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457). |
| Cellular Location | Cytoplasm. Nucleus. Note=Co-localizes with HSP90AB1 in the cytoplasm. Increased nuclear accumulation seen during cell apoptosis |
| Tissue Location | Ubiquitous. |
Research Areas
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Application Protocols
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$ 341.00
Cat# AF4472a
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