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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat anti-LIMK2 (aa181-193) Antibody
Goat anti-LIMK2 (aa181-193) Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, Pep-ELISA |
|---|---|
| Primary Accession | P53671 |
| Other Accession | NP_001026971.1, NP_005560.1, NP_057952.1 |
| Reactivity | Human, Mouse, Rat, Pig |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | LIMK2 |
| Calculated MW | 72232 Da |
| Gene ID | 3985 |
|---|---|
| Other Names | LIMK2; LIM domain kinase 2 |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | This antibody is expected to recognize all reported isoforms (NP_001026971.1; NP_005560.1; NP_057952.1). |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-LIMK2 (aa181-193) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LIMK2 |
|---|---|
| Function | Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11018042). Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP (PubMed:22328514). Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro (PubMed:8537403). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). |
| Cellular Location | Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome [Isoform LIMK2b]: Cytoplasm. Cytoplasm, perinuclear region. Nucleus Note=Mainly present in the cytoplasm and is scarcely translocated to the nucleus. |
Research Areas
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Application Protocols
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$ 341.00
Cat# AF4448a
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