Goat anti-CTDSP1, Biotinylated Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, Pep-ELISA |
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Primary Accession | Q9GZU7 |
Other Accession | NP_067021.1, NP_872580.1, NP_001193807.1 |
Reactivity | Human, Mouse, Rat, Dog, Bovine |
Host | Goat |
Clonality | Polyclonal |
Clone Names | CTDSP1 |
Calculated MW | 29203 Da |
Gene ID | 58190 |
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Other Names | CTDSP1; CTD small phosphatase 1; NIF3; NLI-IF; NLIIF; SCP1; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1; NLI-interacting factor 3; nuclear LIM interactor-interacting factor 3; small C-terminal domain phosphatase 1 |
Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
Immunogen | This antibody is expected to recognize all three reported isoforms (NP_067021.1; NP_872580.1; NP_001193807.1). |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Goat anti-CTDSP1, Biotinylated Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CTDSP1 |
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Synonyms | NIF3, NLIIF, SCP1 |
Function | Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. |
Cellular Location | Nucleus. Note=Colocalizes with RNA polymerase II |
Tissue Location | Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta |
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