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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat anti-CD274 / PD-L1, Biotinylated Antibody
Goat anti-CD274 / PD-L1, Biotinylated Antibody
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, Pep-ELISA |
|---|---|
| Primary Accession | Q9NZQ7 |
| Other Accession | NP_054862.1, NP_001254635.1 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | CD274 |
| Calculated MW | 33275 Da |
| Gene ID | 29126 |
|---|---|
| Other Names | CD274; CD274 molecule; B7-H; B7H1; PD-L1; PDCD1L1; PDCD1LG1; PDL1; B7 homolog 1; CD274 antigen; PDCD1 ligand 1 |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | This antibody is expected to recognize reported isoforms a and b (NP_054862.1; NP_001254635.1) only. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-CD274 / PD-L1, Biotinylated Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CD274 (HGNC:17635) |
|---|---|
| Function | Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813410, PubMed:28813417, PubMed:31399419). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813410, PubMed:28813417, PubMed:36727298). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis (PubMed:32929201). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Recycling endosome membrane; Single-pass type I membrane protein. Nucleus. Note=Associates with CMTM6 at recycling endosomes, where it is protected from being targeted for lysosomal degradation (PubMed:28813417). Translocates to the nucleus in response to hypoxia via its interaction with phosphorylated STAT3 (PubMed:32929201). [Isoform 2]: Endomembrane system; Single-pass type I membrane protein |
| Tissue Location | Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 341.00
Cat# AF4445a
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