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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat anti-UBE2I, Biotinylated Antibody
Goat anti-UBE2I, Biotinylated Antibody
Peptide-affinity purified goat antibody
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- BACKGROUND
Application 
| WB, IHC, ICC, Pep-ELISA |
|---|---|
| Primary Accession | P63279 |
| Other Accession | NP_003336.1 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | UBE2I |
| Calculated MW | 18007 Da |
| Gene ID | 7329 |
|---|---|
| Other Names | UBE2I; ubiquitin-conjugating enzyme E2I; C358B7.1; P18; UBC9; SUMO-1-protein ligase; SUMO-protein ligase; ubiquitin carrier protein 9; ubiquitin carrier protein I; ubiquitin conjugating enzyme 9; ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast); ubi |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | Reported variants represent identical protein: NP_919237.1, NP_003336.1, NP_919236.1, NP_919235.1 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-UBE2I, Biotinylated Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | UBE2I |
|---|---|
| Synonyms | UBC9, UBCE9 |
| Function | Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. Mediates sumoylation of ERCC6 which is essential for its transcription-coupled nucleotide excision repair activity (PubMed:26620705). |
| Cellular Location | Nucleus. Cytoplasm Cytoplasm, perinuclear region Note=Mainly nuclear (By similarity). In spermatocytes, localizes in synaptonemal complexes (PubMed:8610150). Recruited by BCL11A into the nuclear body (By similarity). {ECO:0000250|UniProtKB:P63280, ECO:0000269|PubMed:8610150} |
| Tissue Location | Expressed in heart, skeletal muscle, pancreas, kidney, liver, lung, placenta and brain. Also expressed in testis and thymus. |
Research Areas
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Application Protocols
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$ 341.00
Cat# AF4362a
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