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Goat anti-Plakoglobin / Gamma-catenin, Biotinylated Antibody

Peptide-affinity purified goat antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, Pep-ELISA
Primary Accession P14923
Other Accession NP_002221.1, NP_068831.1
Reactivity Human
Host Goat
Clonality Polyclonal
Clone Names JUP
Calculated MW 81745 Da
Additional Information
Gene ID 3728
Other Names JUP; junction plakoglobin; ARVD12; CTNNG; DP3; DPIII; PDGB; PKGB; catenin (cadherin-associated protein), gamma 80kDa; desmoplakin III; desmoplakin-3
Format Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Immunogen This antibody is expected to recognise both reported isoforms, as represented by NP_002221.1 and NP_068831.1.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat anti-Plakoglobin / Gamma-catenin, Biotinylated Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name JUP (HGNC:6207)
Function Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).
Cellular Location Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Cytoplasm {ECO:0000250|UniProtKB:Q9PVF7}. Cell junction {ECO:0000250|UniProtKB:Q9PVF7}. Nucleus {ECO:0000250|UniProtKB:Q9PVF7} Note=Cytoplasmic in a soluble and membrane-associated form
Tissue Location Expressed in the heart (at protein level).
Research Areas
Citations (0)
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$ 341.00
Cat# AF4357a
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