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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat anti-CBX5 / HP1-Alpha, biotinylated Antibody
Goat anti-CBX5 / HP1-Alpha, biotinylated Antibody
Peptide-affinity purified goat antibody
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- BACKGROUND
Application 
| WB, Pep-ELISA |
|---|---|
| Primary Accession | P45973 |
| Other Accession | NP_036249.1 |
| Reactivity | Human, Mouse, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | CBX5 |
| Calculated MW | 22225 Da |
| Gene ID | 23468 |
|---|---|
| Other Names | CBX5; chromobox homolog 5; HEL25; HP1; HP1A; HP1 alpha homolog; HP1-ALPHA; HP1Hs alpha; antigen p25; chromobox homolog 5 (HP1 alpha homolog, Drosophila); epididymis luminal protein 25; heterochromatin protein 1 homolog alpha; heterochromatin protein 1-alp |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | Reported variants represent identical protein: NP_036249.1, NP_001120793.1, NP_001120794.1 |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-CBX5 / HP1-Alpha, biotinylated Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CBX5 |
|---|---|
| Synonyms | HP1A |
| Function | Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) (PubMed:19783980). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR) (PubMed:19783980). Involved in the formation of kinetochore through interaction with the MIS12 complex subunit NSL1 (PubMed:19783980, PubMed:20231385). Required for the formation of the inner centromere (PubMed:20231385). |
| Cellular Location | Nucleus. Chromosome. Chromosome, centromere. Note=Colocalizes with HNRNPU in the nucleus (PubMed:19617346). Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase (PubMed:19617346). Localizes to sites of DNA damage (PubMed:28977666) |
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Application Protocols
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$ 423.00
Cat# AF4353a
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