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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat anti-ICOS ligand / B7-H2 Antibody
Goat anti-ICOS ligand / B7-H2 Antibody
Peptide-affinity purified goat antibody
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Application 
| WB, Pep-ELISA |
|---|---|
| Primary Accession | O75144 |
| Other Accession | NP_056074.1, NP_001269979.1, NP_001269980.1, NP_001269981.1 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Clone Names | ICOSLG |
| Calculated MW | 33349 Da |
| Gene ID | 23308 |
|---|---|
| Other Names | ICOSLG; inducible T-cell co-stimulator ligand; B7-H2; B7H2; B7RP-1; B7RP1; CD275; GL50; ICOS-L; ICOSL; LICOS; B7 homolog 2; B7 homologue 2; B7-like protein Gl50; B7-related protein 1; ICOS ligand; transmembrane protein B7-H2 ICOS ligand |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | This antibody is expected to recognize all reported isoforms (NP_056074.1; NP_001269979.1; NP_001269980.1; NP_001269981.1). |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat anti-ICOS ligand / B7-H2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ICOSLG |
|---|---|
| Function | Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion (PubMed:11007762, PubMed:11023515, PubMed:30498080). Also induces B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity). In endothelial cells, required for proper neutrophil transmigration in response to chemoattractants, such as CXCL8/IL8 or N-formyl-methionyl peptides (fMLP) (PubMed:30498080). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Expressed on peripheral blood B-cells and monocytes, as well as on monocyte-derived dendritic cells (at protein level). [Isoform 2]: Detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 341.00
Cat# AF4344a
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