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> home > Products > Primary Antibodies > Signal Transduction > Goat Anti-Cyp2r1 (mouse aa405-418)) Antibody
Goat Anti-Cyp2r1 (mouse aa405-418)) Antibody
Peptide-affinity purified goat antibody
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- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q6VVX0 |
| Other Accession | NP_796356.2 |
| Reactivity | Mouse, Rat |
| Predicted | Mouse, Rat |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 100ug/200ul |
| Isotype | IgG |
| Calculated MW | 57359 Da |
| Gene ID | 120227 |
|---|---|
| Other Names | Vitamin D 25-hydroxylase, 1.14.14.24, Cytochrome P450 2R1, CYP2R1 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. |
| Immunogen | Peptide with sequence C-YSVHFDEKYWKDPD, from the internal region of the protein sequence according to NP_796356.2. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-Cyp2r1 (mouse aa405-418)) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CYP2R1 |
|---|---|
| Function | A cytochrome P450 monooxygenase involved in activation of vitamin D precursors. Catalyzes hydroxylation at C-25 of both forms of vitamin D, vitamin D(2) and D(3) (calciol) (PubMed:12867411, PubMed:15465040, PubMed:18511070). Can metabolize vitamin D analogs/prodrugs 1alpha-hydroxyvitamin D(2) (doxercalciferol) and 1alpha-hydroxyvitamin D(3) (alfacalcidol) forming 25-hydroxy derivatives (PubMed:15465040, PubMed:18511070). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:12867411, PubMed:15465040, PubMed:18511070). |
| Cellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein |
Research Areas
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Application Protocols
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$ 423.00
Cat# AF4324a
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