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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Goat Anti-ASCL1 (aa79-91) Antibody
Goat Anti-ASCL1 (aa79-91) Antibody
Purified Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P50553 |
| Other Accession | NP_004307.2, 429, 17172 (mouse), 64186 (rat) |
| Reactivity | Mouse, Rat |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 25454 Da |
| Gene ID | 429 |
|---|---|
| Other Names | ASCL1; achaete-scute complex homolog 1 (Drosophila); ASH1; HASH1; MASH1; bHLHa46; ASH-1; achaete scute protein; achaete-scute complex-like 1; achaete-scute homolog 1; class A basic helix-loop-helix protein 46 |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | Peptide with sequence C-HKSAPKQVKRQRS, from the internal region of the protein sequence according to NP_004307.2. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-ASCL1 (aa79-91) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ASCL1 (HGNC:738) |
|---|---|
| Function | Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Involved in the regulation of neuroendocrine cell development in the glandular stomach (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q02067}. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Fujiwara T, Hiramatsu M, Isagawa T, Ninomiya H, Inamura K, Ishikawa S, Ushijima M, Matsuura M, Jones MH, Shimane M, Nomura H, Ishikawa Y, Aburatani H.
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$ 341.00
Cat# AF4317a
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