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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Anti-Kinesin 1 / UKHC Antibody (C-term), Biotinylated
Anti-Kinesin 1 / UKHC Antibody (C-term), Biotinylated
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | P33176 |
| Other Accession | 3799, NP_004512.1, 16573, 117550 |
| Reactivity | Human, Dog |
| Predicted | Human, Mouse, Rat, Dog |
| Calculated MW | 109685 Da |
| Gene ID | 3799 |
|---|---|
| Other Names | cytoskeletal; ERM; acetylprotein |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Anti-Kinesin 1 / UKHC Antibody (C-term), Biotinylated is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KIF5B (HGNC:6324) |
|---|---|
| Synonyms | KNS, KNS1 |
| Function | Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2- dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). |
| Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q2PQA9}. Cytolytic granule membrane. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side Note=Uniformly distributed between soma and neurites in hippocampal neurons. {ECO:0000250|UniProtKB:Q2PQA9} |
Research Areas
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Application Protocols
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$ 341.00
Cat# AF4276a
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