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> home > Products > Primary Antibodies > Antibody Collections > Viral process > Goat Anti-HLA-B Antibody (internal region)
Goat Anti-HLA-B Antibody (internal region)
Purified Goat Polyclonal Antibody
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Application 
| WB, E |
|---|---|
| Primary Accession | P01889 |
| Other Accession | NP_005505.2 |
| Reactivity | Human |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 |
| Calculated MW | 40460 Da |
| Gene ID | 3106 |
|---|---|
| Other Names | HLA-B; major histocompatibility complex, class I, B; AS; HLAB; SPDA1; HLA class I histocompatibility antigen, B alpha chain; MHC Class I HLA heavy chain; MHC HLA-B cell surface glycoprotein; MHC HLA-B transmembrane glycoprotein; MHC class I antigen GN0010 |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | Peptide with sequence C-RLLRGHDQYAYD , from the internal region of the protein sequence according to NP_005505.2. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-HLA-B Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HLA-B (HGNC:4932) |
|---|---|
| Synonyms | HLAB |
| Function | Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-B-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:23209413, PubMed:25808313, PubMed:29531227, PubMed:9620674). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:18991276, PubMed:7743181). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:24600035, PubMed:29531227, PubMed:9620674). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via constitutive proteasome and IFNG-induced immunoproteasome (PubMed:23209413). Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:25808313, PubMed:29531227). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Biosynthesis of HLA-A and HLA-B antigens in vivo. Owen MJ, Kissonerghis AM, Lodish HF. The Journal of biological chemistry 1980 Oct 255 (20): 9678-84.
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$ 423.00
Cat# AF4266a
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