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Goat Anti-IL3RA / CD123 Antibody (internal region)

Purified Goat Polyclonal Antibody

     
  • WB - Goat Anti-IL3RA / CD123 Antibody (internal region) AF4223a
    AF4223a (2 µg/ml) staining of Jurkat (A) and Molt4 (B) lysates (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P26951
Other Accession NP_002174.1, NP_001254642.1
Reactivity Human
Predicted Human
Host Goat
Clonality Polyclonal
Concentration 0.5
Calculated MW 43330 Da
Additional Information
Gene ID 3563
Other Names IL3RA; interleukin 3 receptor, alpha (low affinity); CD123; IL3R; IL3RAY; IL3RX; IL3RY; hIL-3Ra; CD123 antigen; IL-3 receptor alpha SP2 isoform; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA; interleukin-3 receptor subunit alpha
Format Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Immunogen Peptide with sequence RQQYECLHYKTD, from the internal region of the protein sequence according to NP_002174.1; NP_001254642.1.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-IL3RA / CD123 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL3RA (HGNC:6012)
Synonyms IL3R
Function Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (PubMed:10527461). Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein.
Research Areas
Citations (0)
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References

Identification of CD123+ myeloid dendritic cells as an early-stage immature subset with strong tumoristatic potential. Shi J, Ikeda K, Maeda Y, Shinagawa K, Ohtsuka A, Yamamura H, Tanimoto M. Cancer letters 2008 Oct 270 (1): 19-29.

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$ 341.00
Cat# AF4223a
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