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> home > Products > Primary Antibodies > Antibody Collections > Cytokine > Goat Anti-BMP1 Antibody (internal region)
Goat Anti-BMP1 Antibody (internal region)
Purified Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P13497 |
| Other Accession | 12153(mouse), 83470(rat), NP_001190.1, NP_006120.1 |
| Reactivity | Human |
| Predicted | Human, Mouse, Rat, Pig, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 |
| Calculated MW | 111249 Da |
| Gene ID | 649 |
|---|---|
| Other Names | BMP1; bone morphogenetic protein 1; OI13; PCOLC; PCP; PCP2; TLD; mammalian tolloid protein; procollagen C-endopeptidase; procollagen C-proteinase |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | Peptide with sequence C-DTIVPKYEVNGVK, from the internal region of the protein sequence according to NP_001190.1; NP_006120.1. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-BMP1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BMP1 |
|---|---|
| Synonyms | PCOLC |
| Function | Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins (PubMed:33206546). Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair (PubMed:32636307, PubMed:33169406). Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross- links in collagen and elastic fibers (PubMed:31152061, PubMed:33206546). Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation (PubMed:32636307). |
| Cellular Location | Golgi apparatus, trans-Golgi network. Secreted, extracellular space, extracellular matrix. Secreted. Note=Co-localizes with POSTN in the Golgi. |
| Tissue Location | Ubiquitous. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
The protease domain of procollagen C-proteinase (BMP1) lacks substrate selectivity, which is conferred by non-proteolytic domains. Wermter C, Höwel M, Hintze V, Bombosch B, Aufenvenne K, Yiallouros I, Stöcker W. Biological chemistry 2007 May 388 (5): 513-21.
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$ 341.00
Cat# AF4210a
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