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> home > Products > Primary Antibodies > Antibody Collections > Immunity > Goat Anti-CD74 Antibody (internal region)
Goat Anti-CD74 Antibody (internal region)
Purified Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P04233 |
| Other Accession | NP_001020330.1, NP_004346.1 |
| Reactivity | Human |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 |
| Calculated MW | 33516 Da |
| Gene ID | 972 |
|---|---|
| Other Names | CD74; DHLAG; HLADG; Ia-GAMMA; CD74 molecule, major histocompatibility complex, class II invariant chain; CD74 antigen; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); HLA-DR-gamma; Ia-associated invariant chain; MHC HLA-DR gamma chain; gamma chain of class II antigens |
| Format | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
| Immunogen | Peptide with sequence C-HSLEQKPTDAPPK, from the internal region of the protein sequence according to NP_001020330.1; NP_004346.1. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-CD74 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CD74 (HGNC:1697) |
|---|---|
| Synonyms | DHLAG |
| Function | Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. [Isoform p41]: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform (PubMed:32855215). |
| Cellular Location | Cell membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Secreted. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane |
| Tissue Location | Detected in urine (at protein level). [Isoform p33]: In B cells, represents 70% of total CD74 expression. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
CD74: a potential novel target for triple-negative breast cancer. Tian B, Zhang Y, Li N, Liu X, Dong J. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2012 Dec 33 (6): 2273-7.
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$ 341.00
Cat# AF4183a
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