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Goat Anti-GNL3 Antibody
Goat Anti-GNL3 Antibody (AF4145a)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BVP2 |
| Other Accession | NP_055181.3, NP_996561.1, 26354 |
| Reactivity | Human |
| Predicted | Human |
| Concentration | 100ug/200ul |
| Calculated MW | 61993 Da |
| Gene ID | 26354 |
|---|---|
| Other Names | Guanine nucleotide-binding protein-like 3, E2-induced gene 3 protein, Novel nucleolar protein 47, NNP47, Nucleolar GTP-binding protein 3, Nucleostemin, GNL3, E2IG3, NS |
| Immunogen | Peptide with sequence C-EKNNAQSIRAIKGPH, from the internal region of the protein sequence according to NP_055181.3; NP_996561.1. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-GNL3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GNL3 |
|---|---|
| Synonyms | E2IG3, NS |
| Function | May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q811S9}. Nucleus, nucleolus. Note=Shuttles between the nucleus and nucleolus. {ECO:0000250|UniProtKB:Q811S9} |
| Tissue Location | Increased levels in lung tissue in cancer patients. |
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Provided below are standard protocols that you may find useful for product applications.
Background
May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity).
References
Charpentier A.H.,et al.Cancer Res. 60:5977-5983(2000).
Han C.,et al.Int. J. Mol. Med. 16:205-213(2005).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Andersen J.S.,et al.Curr. Biol. 12:1-11(2002).
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