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Goat Anti-fibrinogen alpha chain (aa123-135) Antibody
Goat Anti-fibrinogen alpha chain (aa123-135) Antibody (AF4140a)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P02671 |
| Other Accession | NP_000499.1, NP_068657.1, 2243 |
| Reactivity | Human |
| Predicted | Human |
| Concentration | 100ug/200ul |
| Calculated MW | 94973 Da |
| Gene ID | 2243 |
|---|---|
| Other Names | Fibrinogen alpha chain, Fibrinopeptide A, Fibrinogen alpha chain, FGA |
| Immunogen | Peptide with sequence C-RDNTYNRVSEDLR, from the internal region of the protein sequence according to NP_000499.1; NP_068657.1. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Goat Anti-fibrinogen alpha chain (aa123-135) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FGA |
|---|---|
| Function | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. |
| Cellular Location | Secreted |
| Tissue Location | Detected in blood plasma (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3- dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.
References
Fu Y.,et al.Biochemistry 31:11968-11972(1992).
Chung D.W.,et al.(In) Ebert R.F. (eds.);
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Chung D.W.,et al.Adv. Exp. Med. Biol. 281:39-48(1990).
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