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Goat Anti-fibrinogen gamma chain Antibody

Peptide-affinity Purified goat antibody

     
  • WB - Goat Anti-fibrinogen gamma chain Antibody AF4127a
    AF4127a (0.1 µg/ml) staining of Human Plasma (A) and Platelets (B) lysates (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P02679
Other Accession NP_000500.2, NP_068656.2, 2266
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 51512 Da
Additional Information
Gene ID 2266
Other Names Fibrinogen gamma chain, FGG
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Immunogen Peptide with sequence C-QDIANKGAKQS, from the internal region of the protein sequence according to NP_000500.2; NP_068656.2.Please note the peptide is available for sale.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGoat Anti-fibrinogen gamma chain Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FGG
Function Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
Cellular Location Secreted
Tissue Location Detected in blood plasma (at protein level).
Citations (0)
citation

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Background

This antibody is expected to recognize both reported isoforms (NP_000500.2; NP_068656.2).

References

The pleiotropic role of the fibrinogen gamma' chain in hemostasis. Uitte de Willige S, Standeven KF, Philippou H, Ariëns RA. Blood 2009 Nov 114 (19): 3994-4001. PMID: 19687509

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$ 341.00
Cat# AF4127a
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