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AMACR (aa312-326) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, Pep-ELISA |
|---|---|
| Primary Accession | Q9UHK6 |
| Other Accession | NP_055139.4, NP_001161067.1, 23600 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 42387 Da |
| Gene ID | 23600 |
|---|---|
| Other Names | Alpha-methylacyl-CoA racemase, 5.1.99.4, 2-methylacyl-CoA racemase, AMACR |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | AMACR (aa312-326) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AMACR |
|---|---|
| Function | Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (PubMed:10655068, PubMed:11060359, PubMed:7649182). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2- (4-isobutylphenyl)propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs (PubMed:10655068, PubMed:11060359, PubMed:7649182). |
| Cellular Location | Peroxisome. Mitochondrion |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize isoform 1 (NP_055139.4) and isoform 3 (NP_001161067.1).
References
High-throughput screen identifies novel inhibitors of cancer biomarker a-methylacyl coenzyme A racemase (AMACR/P504S). Wilson BA, Wang H, Nacev BA, Mease RC, Liu JO, Pomper MG, Isaacs WB. Molecular cancer therapeutics 2011 May 10 (5): 825-38. PMID: 21441411
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