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BCAR1 Antibody (internal region)
Peptide-affinity purified goat antibody
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- CITATIONS
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- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | P56945 |
| Other Accession | NP_001164185.1, NP_001164186.1, NP_001164187.1, NP_001164188.1, NP_001164189.1, NP_055382.2, NP_001164190.1, NP_001164191.1, NP_001164192.1, 9564, 12927 (mouse), 25414 (rat) |
| Reactivity | Human |
| Predicted | Mouse, Rat, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 93372 Da |
| Gene ID | 9564 |
|---|---|
| Other Names | Breast cancer anti-estrogen resistance protein 1, CRK-associated substrate, Cas scaffolding protein family member 1, p130cas, BCAR1, CAS, CASS1, CRKAS |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | BCAR1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BCAR1 |
|---|---|
| Synonyms | CAS, CASS1, CRKAS |
| Function | Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:12832404, PubMed:17038317). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). |
| Cellular Location | Cell junction, focal adhesion. Cytoplasm Cell projection, axon {ECO:0000250|UniProtKB:Q61140} Note=Unphosphorylated form localizes in the cytoplasm (By similarity) Localizes to focal adhesion sites following integrin engagement (By similarity). {ECO:0000250|UniProtKB:Q61140} |
| Tissue Location | Expressed in B-cells (at protein level) (PubMed:9020138). Widely expressed with an abundant expression in the testis (PubMed:10639512). Low level of expression seen in the liver, thymus, and peripheral blood leukocytes (PubMed:10639512) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize reported isoforms1, 2, 3, 5, 6 and 7.
References
BCAR1 protein plays important roles in carcinogenesis and predicts poor prognosis in non-small-cell lung cancer. Huang W, Deng B, Wang RW, Tan QY, He Y, Jiang YG, Zhou JH. PloS one 2012 7 (4): e36124. PMID: 22558353
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