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MDH1 / MOR2 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P40925 |
| Other Accession | NP_001186040.1, NP_005908.1, NP_001186041.1, 4190, 17449 (mouse), 24551 (rat) |
| Reactivity | Human, Mouse, Rat, Pig |
| Predicted | Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 36426 Da |
| Gene ID | 4190 |
|---|---|
| Other Names | Malate dehydrogenase, cytoplasmic, 1.1.1.37, Cytosolic malate dehydrogenase, Diiodophenylpyruvate reductase, 1.1.1.96, MDH1, MDHA |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MDH1 / MOR2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MDH1 {ECO:0000303|PubMed:34012073, ECO:0000312|HGNC:HGNC:6970} |
|---|---|
| Function | Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Catalyzes the reduction of 2-oxoglutarate to 2- hydroxyglutarate, leading to elevated reactive oxygen species (ROS) (PubMed:34012073). |
| Cellular Location | Cytoplasm, cytosol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize all reported isoforms (NP_001186040.1; NP_005908.1; NP_001186041.1).
References
A nucleocytoplasmic malate dehydrogenase regulates p53 transcriptional activity in response to metabolic stress. Lee SM, Kim JH, Cho EJ, Youn HD. Cell Death Differ. 2009 May;16(5):738-48. PMID: 19229245
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