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CAPN1 Antibody (internal region)

Peptide-affinity purified goat antibody

     
  • WB - CAPN1 Antibody (internal region) AF3946a
    AF3946a (0.3 µg/ml) staining of Human Spleen lysate (35 µg protein in RIPA buffer). Detected by chemiluminescence.
    detail
  • IHC - CAPN1 Antibody (internal region) AF3946a
    AF3946a (5 µg/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P07384
Other Accession NP_005177.2, 823
Reactivity Human
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 81890 Da
Additional Information
Gene ID 823
Other Names Calpain-1 catalytic subunit, 3.4.22.52, Calcium-activated neutral proteinase 1, CANP 1, Calpain mu-type, Calpain-1 large subunit, Cell proliferation-inducing gene 30 protein, Micromolar-calpain, muCANP, CAPN1, CANPL1
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCAPN1 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CAPN1 (HGNC:1476)
Synonyms CANPL1
Function Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (PubMed:19617626, PubMed:21531719, PubMed:2400579). Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' (PubMed:23707407). Cleaves and activates caspase-7 (CASP7) (PubMed:19617626).
Cellular Location Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding. In granular keratinocytes and in lower corneocytes, colocalizes with FLG and FLG2 (PubMed:21531719)
Tissue Location Ubiquitous.
Research Areas
Citations (0)
citation

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Background

Reported variants represent identical protein: NP_001185797.1, NP_005177.2, NP_001185798.1.

References

Calpain-1 cleaves Rad21 to promote sister chromatid separation. Panigrahi AK, Zhang N, Mao Q, Pati D. Mol Cell Biol. 2011 Nov;31(21):4335-47. PMID: 21876002

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$ 341.00
Cat# AF3946a
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