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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > PLA2G7 (aa53-64) Antibody (internal region)
PLA2G7 (aa53-64) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q13093 |
| Other Accession | NP_005075.3, 7941 |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 50077 Da |
| Gene ID | 7941 |
|---|---|
| Other Names | Platelet-activating factor acetylhydrolase, PAF acetylhydrolase, 3.1.1.47, 1-alkyl-2-acetylglycerophosphocholine esterase, 2-acetyl-1-alkylglycerophosphocholine esterase, Group-VIIA phospholipase A2, gVIIA-PLA2, LDL-associated phospholipase A2, LDL-PLA(2), PAF 2-acylhydrolase, PLA2G7, PAFAH |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PLA2G7 (aa53-64) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PLA2G7 |
|---|---|
| Synonyms | PAFAH |
| Function | Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response (PubMed:10066756, PubMed:16371369, PubMed:17090529, PubMed:2040620, PubMed:7700381, PubMed:8624782). At the lipid-aqueous interface, hydrolyzes the ester bond of fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:10504265, PubMed:2040620). Specifically targets phospholipids with a short-chain fatty acyl group at sn-2 position (PubMed:2040620). Can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups (PubMed:2040620, PubMed:8624782). Hydrolyzes and inactivates platelet-activating factor (PAF, 1-O-alkyl- 2-acetyl-sn-glycero-3-phosphocholine), a potent pro-inflammatory signaling lipid that acts through PTAFR on various innate immune cells (PubMed:10066756, PubMed:10504265, PubMed:11590221, PubMed:16371369, PubMed:18434304, PubMed:7592717, PubMed:7700381, PubMed:8624782, PubMed:8675689). Hydrolyzes oxidatively truncated phospholipids carrying an aldehyde group at omega position, preventing their accumulation in low-density lipoprotein (LDL) particles and uncontrolled pro-inflammatory effects (PubMed:2040620, PubMed:7700381). As part of high-density lipoprotein (HDL) particles, can hydrolyze phospholipids having long-chain fatty acyl hydroperoxides at sn-2 position and protect against potential accumulation of these oxylipins in the vascular wall (PubMed:17090529). Catalyzes the release from membrane phospholipids of F2-isoprostanes, lipid biomarkers of cellular oxidative damage (PubMed:16371369). |
| Cellular Location | Secreted, extracellular space Note=Associates with both LDL and HDL particles in plasma (PubMed:10066756, PubMed:11590221, PubMed:12821559, PubMed:18434304) Mainly associates with pro-inflammatory electronegative LDL particles (PubMed:12821559). |
| Tissue Location | Plasma (PubMed:11590221, PubMed:12821559). Secreted by macrophages (at protein level) (PubMed:11590221) |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Reported variants represent identical protein: NP_005075.3, NP_001161829.1
References
Lipoprotein-associated phospholipase A2 activity in patients with preserved left ventricular ejection fraction. Moldoveanu E, Serban M, Marta DS, Serban I, Huica R. Biomarkers. 2011 Nov;16(7):587-9. PMID: 21942556
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$ 216.00
Cat# AF3940a
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