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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > MCTS1 Antibody (N-Term)
MCTS1 Antibody (N-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9ULC4 |
| Other Accession | NP_054779.1, NP_001131026.1, 28985 |
| Reactivity | Human |
| Predicted | Pig, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 20555 Da |
| Gene ID | 28985 |
|---|---|
| Other Names | Malignant T-cell-amplified sequence 1, MCT-1, Multiple copies T-cell malignancies, MCTS1, MCT1 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MCTS1 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MCTS1 |
|---|---|
| Synonyms | MCT1 |
| Function | Translation regulator forming a complex with DENR to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post- termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation (PubMed:16982740, PubMed:20713520, PubMed:37875108). This regulatory mechanism governs the translation of more than 150 genes which translation reinitiation is MCTS1/DENR complex-dependent (PubMed:16982740, PubMed:20713520, PubMed:37875108). Consequently, modulates various unrelated biological processes including cell cycle regulation and DNA damage signaling and repair (PubMed:10440924, PubMed:11709712, PubMed:12637315, PubMed:15897892, PubMed:16322206, PubMed:17016429, PubMed:17416211, PubMed:9766643). Notably, it positively regulates interferon gamma immunity to mycobacteria by enhancing the translation of JAK2 (PubMed:37875108). |
| Cellular Location | Cytoplasm. Note=Nuclear relocalization after DNA damage |
| Tissue Location | Ubiquitous. Over-expressed in T-cell lymphoid cell lines and in non-Hodgkin lymphoma cell lines as well as in a subset of primary large B-cell lymphomas. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize both reported isosoforms (NP_054779.1; NP_001131026.1).
References
The antagonism between MCT-1 and p53 affects the tumorigenic outcomes. Kasiappan R, Shih HJ, Wu MH, Choy C, Lin TD, Chen L, Hsu HL. Mol Cancer. 2010 Dec 7;9:311. PMID: 21138557
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$ 423.00
Cat# AF3876a
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