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APEG1 / SPEG Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q15772 |
| Other Accession | NP_005867.3, 10290 |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 354289 Da |
| Gene ID | 10290 |
|---|---|
| Other Names | Striated muscle preferentially expressed protein kinase, 2.7.11.1, Aortic preferentially expressed protein 1, APEG-1, SPEG, APEG1, KIAA1297 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | APEG1 / SPEG Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SPEG |
|---|---|
| Synonyms | APEG1, KIAA1297 |
| Function | Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. |
| Cellular Location | [Isoform 3]: Nucleus. |
| Tissue Location | Isoform 1 is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 is predominantly expressed in the aorta. Isoform 3 appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC in vivo. In response to vascular injuries ASMC dedifferentiate and change from a quiescent and contractile phenotype to a proliferative and synthetic phenotype. This proliferation of vascular smooth muscle cells is one of the most prominent features of atherosclerosis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize isoform 1 only (NP_005867.3).
References
APEG-1, a novel gene preferentially expressed in aortic smooth muscle cells, is down-regulated by vascular injury. Hsieh CM, Yoshizumi M, Endege WO, Kho CJ, Jain MK, Kashiki S, de los Santos R, Lee WS, Perrella MA, Lee ME. J Biol Chem. 1996 Jul 19;271(29):17354-9. PMID: 8663449
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