ABCD2 (aa460-473) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9UBJ2 |
Other Accession | NP_005155.1, 225 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 83233 Da |
Gene ID | 225 |
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Other Names | ATP-binding cassette sub-family D member 2, Adrenoleukodystrophy-like 1, Adrenoleukodystrophy-related protein, hALDR, ABCD2, ALD1, ALDL1, ALDR, ALDRP |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ABCD2 (aa460-473) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ABCD2 (HGNC:66) |
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Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)- CoA from the cytosol to the peroxisome lumen (PubMed:21145416, PubMed:29397936). Like ABCD1 seems to have fatty acyl-CoA thioesterase (ACOT) and ATPase activities, according to this model, VLCFA-CoA as free VLCFA is transpoted in an ATP-dependent manner into peroxisomes after the hydrolysis of VLCFA-CoA mediated by the ACOT activity of ABCD2 (Probable) (PubMed:29397936). Shows overlapping substrate specificities with ABCD1 toward saturated fatty acids (FA) and monounsaturated FA (MUFA) but has a distinct substrate preference for shorter VLCFA (C22:0) and polyunsaturated fatty acid (PUFA) such as C22:6-CoA and C24:6-CoA (in vitro) (PubMed:21145416). Thus, may play a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:21145416). |
Cellular Location | Peroxisome membrane; Multi-pass membrane protein |
Tissue Location | Predominantly expressed in brain and heart. |
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Provided below are standard protocols that you may find useful for product applications.
Background
No cross-reactivity expected with ABCD1.
References
Differential substrate specificities of human ABCD1 and ABCD2 in peroxisomal fatty acid ?-oxidation. van Roermund CW, Visser WF, Ijlst L, Waterham HR, Wanders RJ. Biochim Biophys Acta. 2011 Mar;1811(3):148-52. PMID: 21145416
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