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p15INK4b (isoform 2) Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P42772 |
| Other Accession | NP_004927.2, NP_511042.1, 1030 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 14722 Da |
| Gene ID | 1030 |
|---|---|
| Other Names | Cyclin-dependent kinase 4 inhibitor B, Multiple tumor suppressor 2, MTS-2, p14-INK4b, p15-INK4b, p15INK4B, CDKN2B, MTS2 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | p15INK4b (isoform 2) Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CDKN2B |
|---|---|
| Synonyms | MTS2 |
| Function | Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest. |
| Cellular Location | Cytoplasm. Note=Also found in the nucleus |
| Tissue Location | Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize isoform 2 (NP_511042.1) only.
References
Strategies to re-express epigenetically silenced p15(INK4b) and p21(WAF1) genes in acute myeloid leukemia. Geyer CR. Epigenetics. 2010
Nov-Dec;5(8):696-703. Review. PMID: 21124069
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