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IGF2 (aa81-93) Antibody (internal region)

Peptide-affinity purified goat antibody

     
  • IHC - IGF2 (aa81-93) Antibody (internal region) AF3604a
    AF3604a (5 µg/ml) staining of paraffin embedded Human Cerebellum. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC, E
Primary Accession P01344
Other Accession NP_000603.1, NP_001121070.1, 3481, 16002 (mouse), 24483 (rat)
Reactivity Human
Predicted Mouse, Rat, Pig, Dog
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 20140 Da
Additional Information
Gene ID 3481
Other Names Insulin-like growth factor II, IGF-II, Somatomedin-A, T3M-11-derived growth factor, Insulin-like growth factor II, Insulin-like growth factor II Ala-25 Del, Preptin, IGF2
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIGF2 (aa81-93) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IGF2
Function The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (PubMed:28873464). Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity).
Cellular Location Secreted.
Tissue Location Expressed in heart, placenta, lung, liver, muscle, kidney, tongue, limb, eye and pancreas.
Research Areas
Citations (0)
citation

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Background

This antibody is expected to recognize both reported isoforms (NP_000603.1; NP_001121070.1). Reported variants represent identical protein: NP_000603.1, NP_001007140.2

References

Long range interactions regulate Igf2 gene transcription during skeletal muscle differentiation. Alzhanov DT, McInerney SF, Rotwein P. J Biol Chem. 2010 Dec 10;285(50):38969-77. PMID: 20937833

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$ 341.00
Cat# AF3604a
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