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ADAM12 (aa225-239) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O43184 |
| Other Accession | NP_003465.3, NP_067673.2, 8038, 11489 (mouse), 679837 (rat) |
| Reactivity | Human, Mouse, Rat |
| Predicted | Pig |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 99542 Da |
| Gene ID | 8038 |
|---|---|
| Other Names | Disintegrin and metalloproteinase domain-containing protein 12, ADAM 12, 3.4.24.-, Meltrin-alpha, ADAM12, MLTN |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ADAM12 (aa225-239) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ADAM12 |
|---|---|
| Synonyms | MLTN |
| Function | Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity). |
| Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein [Isoform 3]: Secreted. |
| Tissue Location | Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize both reported isoforms (NP_003465.3; NP_067673.2).
References
Z-DNA-forming silencer in the first exon regulates human ADAM-12 gene expression. Ray BK, Dhar S, Shakya A, Ray A. Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):103-8. PMID: 21173277
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