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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > JAG1 Antibody (C-Term)
JAG1 Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC, E |
|---|---|
| Primary Accession | P78504 |
| Other Accession | NP_000205.1, 182, 16449 (mouse), 29146 (rat) |
| Reactivity | Human |
| Predicted | Mouse, Rat, Pig, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 133799 Da |
| Gene ID | 182 |
|---|---|
| Other Names | Protein jagged-1, Jagged1, hJ1, CD339, JAG1, JAGL1 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | JAG1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | JAG1 |
|---|---|
| Synonyms | JAGL1 |
| Function | Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (PubMed:18660822, PubMed:20437614). May be involved in cell-fate decisions during hematopoiesis (PubMed:9462510). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro). |
| Cellular Location | Membrane; Single-pass type I membrane protein. Cell membrane |
| Tissue Location | Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Plasminogen activator uPA is a direct transcriptional target of the JAG1-Notch receptor signaling pathway in breast cancer. Shimizu M, Cohen B, Goldvasser P, Berman H, Virtanen C, Reedijk M. Cancer Res. 2011 Jan 1;71(1):277-86. PMID: 21199807
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$ 341.00
Cat# AF3557a
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