MTHFD1L (aa535-538) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q6UB35 |
Other Accession | NP_056255.2, 25902, 270685 (mouse), 361472 (rat) |
Reactivity | Human, Mouse, Rat |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 105790 Da |
Gene ID | 25902 |
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Other Names | Monofunctional C1-tetrahydrofolate synthase, mitochondrial, 6.3.4.3, Formyltetrahydrofolate synthetase, MTHFD1L, FTHFSDC1 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | MTHFD1L (aa535-538) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MTHFD1L (HGNC:21055) |
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Synonyms | FTHFSDC1 |
Function | May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2. |
Cellular Location | Mitochondrion. |
Tissue Location | Detected in most tissues, highest expression found in placenta, thymus and brain. Low expression is found in liver and skeletal muscle. Up-regulated in colon adenocarcinoma |
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Provided below are standard protocols that you may find useful for product applications.
References
A common variant in MTHFD1L is associated with neural tube defects and mRNA splicing efficiency. Parle-McDermott A, Pangilinan F, O'Brien KK, Mills JL, Magee AM, Troendle J, Sutton M, Scott JM, Kirke PN, Molloy AM, Brody LC, Human mutation 2009 Dec 30 (12): 1650-6. PMID: 19777576
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