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Scn10a / Nav1.8 (mouse) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q9Y5Y9 |
| Other Accession | NP_033160.2, 6336, 20264 (mouse), 29571 (rat) |
| Predicted | Mouse, Rat |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 220626 Da |
| Gene ID | 6336 |
|---|---|
| Other Names | Sodium channel protein type 10 subunit alpha, Peripheral nerve sodium channel 3, PN3, hPN3, Sodium channel protein type X subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.8, SCN10A |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Scn10a / Nav1.8 (mouse) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SCN10A (HGNC:10582) |
|---|---|
| Function | Tetrodotoxin-resistant channel that mediates the voltage- dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:D0E0C2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:D0E0C2}. Note=It can be translocated to the cell membrane through association with S100A10 |
| Tissue Location | Expressed in the dorsal root ganglia and sciatic nerve. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Transmembrane segments prevent surface expression of sodium channel Nav1.8 and promote calnexin-dependent channel degradation. Li Q, Su YY, Wang H, Li L, Wang Q, Bao L, The Journal of biological chemistry 2010 Oct 285 (43): 32977-87. PMID: 20720009
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